Synthesis, structure–activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-Chloro-N 2-(2- …

TH Marsilje, W Pei, B Chen, W Lu, T Uno…

文献索引：Journal of Medicinal Chemistry, , vol. 56, # 14 p. 5675 - 5690

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被引用次数: 146

摘要

... Journal of Medicinal Chemistry. ... Multiple pharmaceutical companies have described ALK inhibitors (ALKi) at various stages of development.(16-24) Structures of ALKi in clinical development are depicted in Figure 1. Compound 1 (PF-02341066, crizotinib)(25-28) was ...