A New Generation of Specific Trypanosoma cruzi trans??Sialidase Inhibitors

S Buchini, A Buschiazzo…

文献索引：Buchini, Sabrina; Buschiazzo, Alejandro; Withers, Stephen G. Angewandte Chemie - International Edition, 2008 , vol. 47, # 14 p. 2700 - 2703

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被引用次数: 73

摘要

The protozoan parasite Trypanosoma cruzi is the causative agent of human American trypanosomiasis, also known as Chagas disease, which in its chronic form can lead to severe debilitation and ultimately death.[1] According to World Health Organization (WHO) estimates, 16 to 18 million people were infected in Latin America in 2005. Only two approved drugs (nifurtimox and benznidazole) are currently used for the treatment of the ...