Synthesis, 18F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors

MB Skaddan, MR Kilbourn, SE Snyder…

文献索引：Chi, Dae Yoon; Kiesewetter, Dale O.; Katzenellenbogen, John A. Journal of Fluorine Chemistry, 1986 , vol. 31, p. 99 - 114

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被引用次数: 26

摘要

... Journal of Medicinal ... Moreover, addition of fluorine to an existing alkyl substituent also lowered binding affinity (eg CH 2 CH 3 to CH 2 CH 2 F). However, these observations do not indicate simple steric ... compd, n, ring position, R, mp (°C) b, yield (%) c, log P o/w d, K i (nM) e. ...