Tetrahedron letters

An approach towards the synthesis of oligomers containing a N-2-hydroxyethyl-aminomethylphosphonate backbone: A novel PNA analogue

…, E Kuyl-Yeheskiely, VA Efimov, OG Chakhmakhcheva

文献索引：Van Der Laan, Alexander C.; Stroemberg, Roger; Van Boom, Jacques H.; Kuyl-Yeheskiely, Esther; Efimov, Vladimir A.; Chakhmakhcheva, Oksana G. Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7857 - 7860

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被引用次数: 57

摘要

A convenient route to the preparation of 4-methoxy-1-oxido-pyridine-2-methyl N-2-(4, 4′- dimethoxytrityloxy) ethyl-N-thymin-1-yl-aminomethylphosphonate (1a, T∗) and the corresponding N4-benzoylcytosin-1-yl derivative 1b (C∗) is reported. These PPNA monomers proved to be suitable building blocks in a solid-support synthesis of the tetradecameric fragment (C∗ T∗ T∗ T∗ C∗ T∗ T∗ T∗ T∗ C∗ T∗ C∗ T∗) dT.