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Quinazolinone derivatives: synthesis and binding evaluation on cholecystokinin receptors

A Varnavas, L Lassiani, E Luxich, M Zacchigna…

文献索引：Varnavas; Lassiani; Luxich; Zacchigna; Boccu Farmaco, 1996 , vol. 51, # 5 p. 333 - 339

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被引用次数: 9

摘要

Résumé/Abstract A series of 2-methyl-3-amino-4 (H)-quinazolinone and of 2-phenyl-3- amino-4 (H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4 (3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands