Angular furoquinolinones, psoralen analogs: Novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided …

…, S Caffieri, A Pozzan, F Dall'Acqua

文献索引：Rodighiero, Paolo; Guiotto, Adriano; Chilin, Adriana; Bordin, Franco; Baccichetti, Francarosa; Carlassare, Francesco; Vedaldi, Daniela; Caffieri, Sergio; Pozzan; Dall'Acqua, Francesco Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1293 - 1302

全文：HTML全文

被引用次数: 51

摘要

With the aim of obtaining new potential photochemotherapeutic agents, having increased antiproliferative activity and decreased undesired effects, we have prepared some new furoquinolinones. Two of them have been studied in detail: 1, 4, 6, 8-tetramethyl-2 H-furo [2, 3-h] quinolin-2-one (8), and 4, 6, 8, 9-tetramethyl-2 H-furo [2, 3-h] quinolin-2-one (10). These compounds form a molecular complex with DNA, undergoing intercalation inside the ...