Synthesis of Benzo [s] picene and its Putative Carcinogenic trans-3, 4-Dihydrodiol and Fjord Region anti-Diol Epoxide Metabolites

RG Harvey, JT Zhang, E Luna…

文献索引：Harvey,R. G.; Zhang, J.-T.; Luna, E.; Pataki, J. Journal of Organic Chemistry, 1998 , vol. 63, # 18 p. 6405 - 6408

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被引用次数: 11

摘要

Our interest in 1 was stimulated by its potential carcinogenicity; that is, it has two fjord regions, a structural feature characteristic of some of the most potent carcinogenic hydrocarbons known (eg dibenzo [def, p] chrysene2 and benzo [g] chrysene3). Like both of these polyarenes, 1 is presumed to be distorted from planarity due to steric interference between the fjord region atoms. 4