Potent hepatitis C virus NS5A inhibitors containing a benzidine core
IH Bae, JK Choi, C Chough, SJ Keum…
文献索引：Bae, Il Hak; Choi, Jin Kyu; Chough, Chieyeon; Keum, Sun Ju; Kim, Heesun; Jang, Sung Key; Kim, B. Moon ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 3 p. 255 - 258
Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.
