Tetrahedron: Asymmetry

Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands

L Palais, A Alexakis

文献索引：Palais, Laetitia; Alexakis, Alexandre Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2866 - 2870

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被引用次数: 10

摘要

Herein we report the copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic and acyclic enones, with SimplePhos as chiral ligands. A variety of Grignard reagents can be added to a range of cyclic and acyclic enones, with moderate to good enantioselectivities (ee's up to 86%).