Kinetic resolution of piperazine-2-carboxamide by leucine aminopeptidase. An application in the synthesis of the nucleoside transport blocker (-) draflazine

…, DR St. Laurent, GS Poindexter, I Monkovic…

文献索引：Bruce; St. Laurent; Poindexter; Monkovic; Huang; Balasubramanian Synthetic Communications, 1995 , vol. 25, # 17 p. 2673 - 2684

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被引用次数: 23

摘要

Abstract The resolution of Nt-Boc-piperazine carboxamide 5 proceeded smoothly in the presence of leucine aminopeptidase to produce acid (S)-1 and amide (R)-5 with good optical purity. Sequential alkylation and functional group manipulation of carboxamide (S)-5 provided the known nucleoside transport blocker draflazine (-) 2.