Bioorganic & medicinal chemistry letters

Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2′, 3′-didehydro-2′, 3′-dideoxyadenosine

P Wang, RF Schinazi, CK Chu

文献索引：Wang, Peiyuan; Schinazi, Raymond F.; Chu, Chung K. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 13 p. 1585 - 1588

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被引用次数: 23

摘要

Asymmetric synthesis of l-carbocyclic 2′, 3′-didehydro-2′, 3′-dideoxyadenosine and its analogs were accomplished and their anti-HIV activities were evaluated. It was found that l- carbocyclic 2′, 3′-didehydro-2′, 3′-dideoxyadenosine exhibited moderately potent anti- HIV (EC50= 2.4 μM) activity in human PBM cells without cytotoxicity up to 100 μM.