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Synthesis of Tetrahydro??2 (1 H) quinazolinones, Cyclopenta [d]??2 (1 H) pyrimidinones, and Their Thioxo Analogs from 2??Trifluoroacetyl??1??methoxycycloalkenes

…, MR Oliveira, RL Drekener, MAP Martins…

文献索引:Bonacorso, Helio G.; Costa, Michelle B.; Lopes, Itamar S.; Oliveira, Marli R.; Drekener, Roberta L.; Martins, Marcos A. P.; Zanatta, Nilo; Flores, Alex F. C. Synthetic Communications, 2005 , vol. 35, # 23 p. 3055 - 3064

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被引用次数: 18

摘要

Abstract A series of six (8)??alkyl??4??trifluoromethyl??5, 6, 7, 8??tetrahydro??2 (1 H) quinazolinones, 4??trifluoromethyl??cyclopenta [d]??2 (1 H) pyrimidinones, and their thioxo analogs from the reaction of five β??alkoxyvinyl trifluoromethyl ketones, derived from alkylated cyclohexanones and cyclopentanone with urea and thiourea, is reported. The reactions were carried out in a single step in propan??2??ol as solvent and boron trifluoride ...