… nitrogen-carbon-linked (azolylphenyl) oxazolidinones with expanded activity against the fastidious gram-negative organisms haemophilus i nfluenzae and moraxella c …

…, MR Barbachyn, DE Emmert, SA Garmon…

文献索引：Genin, Michael J.; Allwine, Debra A.; Anderson, David J.; Barbachyn, Michael R.; Emmert, D. Edward; Garmon, Stuart A.; Graber, David R.; Grega, Kevin C.; Hester, Jackson B.; Hutchinson, Douglas K.; Morris, Joel; Reischer, Robert J.; Ford, Charles W.; Zurenko, Gary E.; Hamel, Judith C.; Schaadt, Ronda D.; Stapert, Douglas; Yagi, Betty H. Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 953 - 970

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被引用次数: 701

摘要

A series of new nitrogen-carbon-linked (azolylphenyl) oxazolidinone antibacterial agents has been prepared in an effort to expand the spectrum of activity of this class of antibiotics to include Gram-negative organisms. Pyrrole, pyrazole, imidazole, triazole, and tetrazole moieties have been used to replace the morpholine ring of linezolid (2). These changes resulted in the preparation of compounds with good activity against the fastidious Gram- ...