N-Alkyl-N-(5-isothiazolyl)-and N-(Alkylisothiazolin-5-ylidene)-phenylacetamides. Synthesis and Biological Activity

…, TJ Bruce, JE Dripps, J Gifford, CJ Hatton…

文献索引：Samaritoni, Jack G.; Arndt, Lena; Bruce, Timothy J.; Dripps, James E.; Gifford, James; Hatton, Christopher J.; Hendrix, William H.; Schoonover, Joseph R.; Johnson, George W.; Hegde, Vidyadhar B.; Thornburgh, Scott Journal of Agricultural and Food Chemistry, 1997 , vol. 45, # 5 p. 1920 - 1930

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被引用次数: 7

摘要

Treatment of 5-amino-4-chloro-3-methylisothiazole (3) with the acid chloride of [p-[(α, α, α- trifluoro-p-tolyl) oxy] phenyl] acetic acid (6) afforded the amide N-(4-chloro-3-methyl-5- isothiazolyl)-2-[p-[(α, α, α-trifluoro-p-tolyl) oxy] phenyl] acetamide (1), which was substituted with various alkyl groups in an effort to alleviate toxicity toward non-target organisms through a proinsecticide approach. Alkylations of 1 under a variety of reaction conditions afforded ...