A 10-step, asymmetric synthesis of (S)-camptothecin

DL Comins, MF Baevsky, H Hong

文献索引：Comins; Baevsky; Hong Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10971 - 10972

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被引用次数: 133

摘要

(S)-Camptothecin (l), a pentacyclic alkaloid isolated from Cumptotheca acuminata by Wall and co-workers in 1966, con-tinues to be one of the most important lead compounds among the anticancer natural products.'A number of promising analogs have been prepared that show improved solubility, low overall toxicity, and impressive in vivo activity against certain solid tumors.* Some of the more active derivatives include 9-aminocamptothecin"(2), 10, l l ...