Preparation of highly potent and selective non-peptide antagonists of the arginine vasopressin V1A receptor by introduction of a 2-ethyl-1H-1-imidazolyl group
To find a new series of arginine vasopressin (AVP) V 1A receptor antagonists, the influence of the 2-phenyl group of 2-phenyl-4′-[(2, 3, 4, 5-tetrahydro-1H-1-benzazepin-1-yl) carbonyl] benzanilide (7) was investigated. Replacement of the 2-phenyl group by a 2-ethyl-1H- imidazol-1-yl group was effective in yielding a V 1A-selective compound. Moreover, this imidazolyl group was introduced in the same position in YM-35471 (6), and further studies ...
