Self-assembly to function: design, synthesis, and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides

…, SN Benke, N Nagendra, PL Srivastava…

文献索引：Shankar, S. Shiva; Benke, Sushil N.; Nagendra, Narem; Srivastava, Prabhakar Lal; Thulasiram, Hirekodathakallu V.; Gopi, Hosahudya N. Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8468 - 8474

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被引用次数: 6

摘要

Nonribosomal E-vinylogous γ-amino acids are widely present in many peptide natural products and have been exploited as inhibitors for serine and cysteine proteases. Here, we are reporting the broad spectrum antimicrobial properties and self-assembled nanostructures of various hybrid lipopeptides composed of 1: 1 alternating α-and E- vinylogous residues. Analysis of the results revealed that self-assembled nanostructures ...