Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl) ethyl]-5-ethyl-6-methylpyridin-2 (1H)- …

…, DL Bamberger, JL Barnes, TM Williams

文献索引：Hoffman; Smith; Rooney; Fisher; Wai; Thomas; Bamberger; Barnes; Williams; Jones; Olson; O'Brien; Goldman; Nunberg; Quintero; Schleif; Emini; Anderson Journal of Medicinal Chemistry, 1993 , vol. 36, # 8 p. 953 - 966

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被引用次数: 78

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61 le (a) PC15, 140 OC; MeONa, MeOH, reflux; Hz, Pd/C, MeOH, Tl F;(b) m- chloroperbenzoic acid, CHCl3; HOAc, H20;(c) NaN02,% HzS04, lOO OC;(d) NaN02, aqueous HCI; NaSC (S) OEt; NaOH; e) NaH, THF, ArCH2C1;(0 Et3N, ArCHzCl, EtOH (g) KI, HOAc 10 OC;(h) rn-chloroperbenzoic acid, CHC13. For 35, Ar is benzoxazol-2-yl; 36-39, Ar is 4, 7-dichlorobenzoxazol-2-yl. employed a variety of synthetically incompatible ...