Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea

SK Kashaw, V Kashaw, P Mishra, NK Jain…

文献索引：Kashaw, Sushil K.; Kashaw, Varsha; Mishra, Pradeep; Jain; Stables European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4335 - 4343

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被引用次数: 83

摘要

Several new 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea were synthesized and screened for anticonvulsant, CNS depressant and sedative-hypnotic activity in the mice. After ip injection to mice at doses of 30, 100, and 300mg/kg body weight synthesized compounds were examined in the maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. ...