Preparation of racemic and enantiomerically enriched N-phenyl-and N-benzyl-3, 3, 3- trifluorolactic acid amides has been developed. These compounds were found to have substantial magnitude of the self-disproportionation of enantiomers (SDE) via sublimation. For example, when N-phenyl-3, 3, 3-trifluorolactic acid amide of 87% ee was sublimed (12h) from a Petri dish at 80° C open to the atmosphere, the enantiomeric excess of the ...
