A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.

…, C SERGHERAERT, E DAVIOUD-CHARVET

文献索引：Salmon, Laurence; Landry, Valerie; Melnyk, Oleg; Maes, Louis; Sergheraert, Christian; Davioud-Charvet, Elisabeth Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 707 - 710

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被引用次数: 11

摘要

A simplified approach to the synthesis of 2-polyamine linked-monoindolylmaleimides has been achieved, leading to a new series of trypanothione reductase inhibitors. The conditions of access to N, 2-bis (polyamine)-3-monoindolylmaleimides and N, N'-bis ( monoindolylmaleimide) polyamines are described. Measured inhibitory activities towards trypanothione reductase from Tryanosoma cruzi show the importance of both aromatic ...