Synthesis of enantiomerically pure α-[4-(1-substituted)-1, 2, 3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential …
Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave- assisted Cu (I)-catalyzed 'click chemistry'approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1, 2, 3-triazol-4-yl] benzylacetamides starting from racemic propargylamines. These compounds could ...
