Growth inhibition and induction of cellular differentiation of human myeloid leukemia cells in culture by carbamoyl congeners of ribavirin

…, BK Bhattacharya, GD Kini, SS Matsumoto…

文献索引：Sanghvi, Yogesh S.; Bhattacharya, Birendra K.; Kini, Ganesh D.; Matsumoto, Steven S.; Larson, Steven B.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 336 - 344

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被引用次数: 87

摘要

A series of 1, 2, 3-triazole (2), pyrazole (3 and 5), and pyrrole (4) ribonucleosides with two adjacent carbamoyl groups have been synthesized and evaluated for cell growth inhibition and induction of cellular differentiation of HL-60 cells in culture. Glycosylation of the TMS derivatives of dimethyl 1, 2, 3-triazole-4, 5-dicarboxylate(6) and diethyl pyrazole-3, 4- dicarboxylate (7) with 1-0-acetyl-2, 3, 5-tri-O-benzoyl-~-ribofuranose (8) in the presence of ...