A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4′??Deoxychitobiosyl)??4??methylumbelliferone
J Dinkelaar, BA Duivenvoorden…
文献索引：Dinkelaar, Jasper; Duivenvoorden, Boudewijn A.; Wennekes, Tom; Overkleeft, Herman S.; Boot, Rolf G.; Aerts, Johannes M. F. G.; Codee, Jeroen D. C.; Van Der Marel, Gijs A. European Journal of Organic Chemistry, 2010 , # 13 p. 2565 - 2570
Abstract To meet the increasing clinical demand for the diagnostic agent (4′- deoxychitobiosyl)-4-methylumbelliferone, a flexible and scalable route of synthesis is needed. In this paper such a route is presented. The key to the route is the use of a partially protected thiophenyl glucosamine as starting material for the preparation of both the reducing and nonreducing end building blocks of the 4′-deoxychitobiose disaccharide.
