Pyrazole CCK 1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free–Wilson additivity

…, L Li, TD Barrett, N Shankley, JG Breitenbucher

文献索引：McClure, Kelly; Hack, Michael; Huang, Liming; Sehon, Clark; Morton, Magda; Li, Lina; Barrett, Terrance D.; Shankley, Nigel; Breitenbucher, J. Guy Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 72 - 76

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被引用次数: 25

摘要

High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free–Wilson) and non-additive ...