Bioorganic & medicinal chemistry letters

Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H 37 Rv

AV Shindikar, CL Viswanathan

文献索引：Shindikar, Anand V.; Viswanathan Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1803 - 1806

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被引用次数: 62

摘要

Novel 6, 8-difluoro-1-alkyl-5-amino-1, 4-dihydro-4-oxo-7-{4-substituted piperazin-1-yl}- quinoline-3-carboxylic acids, with the substituents at 4th position of piperazine being-[2 (pyridine-4-carbonyl) hydrazono] propyl and-2 [(pyrazine-2-carbonyl) amino] ethyl, were synthesized and evaluated in vivo against Mycobacterium tuberculosis H37Rv in Swiss albino mice. Test compounds exhibited activity comparable to that of sparfloxacin (survival ...