Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells

…, A Krämer, TO Larsen, MH Clausen

文献索引：Ronnest, Mads H.; Rebacz, Blanka; Markworth, Lene; Terp, Anette H.; Larsen, Thomas O.; Kraemer, Alwin; Clausen, Mads H. Journal of Medicinal Chemistry, 2009 , vol. 52, # 10 p. 3342 - 3347

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被引用次数: 15

摘要

Griseofulvin and 53 analogues of this compound have been tested against the pathogenic dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes as well as against the breast cancer cell line MDA-MB-231. The modifications to griseofulvin include the 4, 5, 6, 2′, 3′, and 4′ positions. The SAR of the griseofulvin analogues toward the two fungi followed the same trend with the majority being less active than griseofulvin and none had ...