Synthesis and biological activity of 2-phenylethyl-3-hydroxypyridines

VI Kuz'min, AS Losev, IS Morozov, EP Pavlova…

文献索引：Kuz'min, V. I.; Losev, A. S.; Morozov, I. S.; Pavlova, E. P.; Samoilov, N. N.; et al. Pharmaceutical Chemistry Journal, 1993 , vol. 27, # 8 p. 555 - 561 Khimiko-Farmatsevticheskii Zhurnal, 1993 , vol. 27, # 8 p. 19 - 24

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摘要

The resulting 2-phenylethyl-3-hydroxypyridines, containing methoxy groups in the phenyl ring, were demethylated by boiling with 48% HBr, to form compounds XII-XIV, and iodination of 2-phenylethyl-3-hydroxypyridines in a 10% aqueous solution of soda with iodine in the presence of KI was used to form the 6-iodo derivative of 3-hydroxypyridine (XV), with subsequent replacement of the iodine atom with a methoxy group (XVI).