Synthesis and cytotoxic activity of new azepino [3′, 4′: 4, 5] pyrrolo [2, 1-a] isoquinolin-12-ones

R Martínez, MM Arzate, MT Ramírez-Apan

文献索引：Martinez, Roberto; Arzate, Martha Menes; Ramirez-Apan, Ma. Teresa Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 1849 - 1856

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被引用次数: 9

摘要

A series of azepino [3′, 4′: 4, 5] pyrrolo [2, 1-a] isoquinolin-12-ones (3a–f), that were conformationally restricted analogs of lead compound 2, were designed as potential cytotoxic compounds and synthesized using a radical oxidative aromatic substitution reaction as the key step. Compounds 3a–f were tested on five tumor cell lines to determine the conformational requirements for biological activity of compound 2. The results show ...