Characterization of directly acting mutagens produced from N-nitroso-N-(formylmethyl) alkylamines: Their possible involvement in the carcinogenesis of N- …
…, M OSABE, M MOCHIZUKI, Y WAKABAYASHI…
文献索引：Suzuki; Osabe; Mochizuki; Wakabayashi; Okada Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4022 - 4030
Directly acting mutagens formed from N-nitroso-N-(formylmethyl) alkylamines (3) were isolated and identified as N-nitroso-N-alkyl-1-hydroxyimino-2-oxoethylamines (4). Their structures were elucidated on the basis of nuclear magnetic resonance spectra and confirmed by derivatization to the crystalline 2, 4-dinitrophenylhydrazones (5). Compounds 4 (alkyl= ethyl and butyl) were strongly mutagenic to Salmonella typhimurium TA 1535 and ...
