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Guanidine analogs of β-adrenergic blocking agents. II. Synthesis and study of arylaminopropanolguanidines

LMM Stankevichene, RAS Smailene…

文献索引:Stankevichene,L.-M. et al. Pharmaceutical Chemistry Journal, 1978 , vol. 12, # 5 p. 595 - 601 Khimiko-Farmatsevticheskii Zhurnal, 1978 , vol. 12, # 5 p. 47 - 53

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摘要

We have tried to substitute the aryloxy group in l-aryloxy-2-oxy-3-guanidinopropanes with an arylamino group offering better synthetic possibilities. In the case of Inderal, such a substitution led to disappearance of the B-adrenoblocking properties [2]. In the synthesis of