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Improved procedure for the reduction of N-acyloxazolidinones

…, RA Haack, VJ Kalish, JM Miyashiro…

文献索引:Penning, Thomas D.; Djuric, Stevan W.; Haack, Richard A.; Kalish, Vincent J.; Miyashiro, Julie M.; et al. Synthetic Communications, 1990 , vol. 20, # 2 p. 307 - 312

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被引用次数: 141

摘要

Thomas D. Penning*, Stevan W. Djuric', Richard A. Haack, Vincent J. Kalish, Julie M. Miyashiro. Bruce W. Rowell, and Stella S. Yu ... Skokie, Illinois 60077 Searle Research and Development, Division of GD Searle & Co. ... During the synthesis of a series of chiral intermediates which utilized Evans' chiral oxazolidinone methodology, we experienced disappointing yields for the nondestructive reductive removal of the chiral auxiliary (eq. 1). When substantial