Tetrahedron

Highly efficient palladium-catalyzed Suzuki–Miyaura reactions of potassium aryltrifluoroborates with 5-iodo-1, 3-dioxin-4-ones in water: an approach to α-aryl-β- …

…, RLOR Cunha, CF Klitzke, J Zukerman-Schpector…

文献索引：Vieira, Adriano S.; Cunha, Rodrigo L.O.R.; Klitzke, Clecio F.; Zukerman-Schpector, Julio; Stefani, Helio A. Tetrahedron, 2010 , vol. 66, # 3 p. 773 - 779

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被引用次数: 5

摘要

The high efficient palladium-catalyzed Suzuki–Miyaura reactions of potassium aryltrifluoroborates 3 with 5-iodo-1, 3-dioxin-4-ones 2a–b in water as only solvent in the presence of n-Bu4NOH as base is reported. The respective 5-aryl-1, 3-dioxin-4-ones 4a–n were obtained in good to excellent yields. The catalyst system provides high efficiency at low load using electronically diverse coupling partners. The obtained 2, 2, 6-trimethyl-5-aryl-1, ...