New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection

…, AD Shved, AM Boguszewska-Chachulska

文献索引：Stankiewicz-Drogon, Anna; Palchykovska, Larisa G.; Kostina, Valentina G.; Alexeeva, Inna V.; Shved, Anatoly D.; Boguszewska-Chachulska, Anna M. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 19 p. 8846 - 8852

全文：HTML全文

被引用次数: 61

摘要

A new class of compounds—acridone derivatives—was tested using the direct fluorometric helicase activity assay to determine the inhibitory properties of the derivatives towards the NS3 helicase of Hepatitis C virus (HCV). The compounds were also tested as putative transcription inhibitors of in vitro transcription based on the DNA-dependent T7 RNA polymerase. Most of the acridone derivatives tested were transcription inhibitors; however, ...