N-(cyanomethyl)-and N-(2-methoxy-1-cyanoethyl) anthracyclines and related carboxyl derivatives

…, DG Streeter, JA Filppi, RL Wolgemuth

文献索引：Acton; Tong; Taylor; Streeter; Filppi; Wolgemuth Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2074 - 2079

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被引用次数: 7

摘要

13 HN (CH, CN) CH, COONa 14 5.3 2.2 0.03 Mice injected ip with lo6 P388 cells on day 0 and then treated ip. T/C= average survival time of treated mice/control mice= antitumor efficacy and must be 2120% for active result. bED60= drug concentration for 50% inhibition of the incorporation of [3H] thymidine in the DNA or [3H] uridine in the RNA of actively growing L1210 cells in culture, after 3 h of exposure. Drugs were initially dissolved in ...