Lead Diversification 2: Application to P38, gMTP and lead compounds

…, M Bazin, ME Bunnage, A Calabrese, M Cox…

文献索引：Masood, M. Abid; Bazin, Marc; Bunnage, Mark E.; Calabrese, Andrew; Cox, Mark; Fancy, Sally-Ann; Farrant, Elizabeth; Pearce, David W.; Perez, Manuel; Hitzel, Laure; Peakman, Torren Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1255 - 1262

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被引用次数: 6

摘要

Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.