Synthesis of 1, 3-bis-(p-alkoxybenzoyl)-1-bis-(2-chloroethyl) aminomethylbut-3-ene hydrochlorides and an examination of their antitumor and antibacterial activity

…, RT Grigoryan, KG Samvelyan, AA Chachoyan…

文献索引：Petrosyan, L. M.; Gevorgyan, G. A.; Grigoryan, R. T.; Samvelyan, K. G.; Chachoyan, A. A.; et al. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 7 p. 448 - 452 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 7 p. 800 - 804

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摘要

Compounds (II-IX) are colorless, crystalline solids with sharp melting points. Their IR spectra show absorption for the C= O group at 1680-1670 cm-~ and for C= CHa at 1640 cm-~. The fragmentation diagrams of the compounds (If-IX), obtained by mass spectrometry show that all the fragments formed under electron impact are consistent with the formulae given (Table i). The antitumor and antibacterial activities of the compounds have been studied. The ...