New. alpha.-methylene. gamma.-lactone derivatives of substituted nucleic acid bases as potential anticancer agents

…, S Mitra, P Pal, SK Chakraborti

文献索引：Sanyal, Utpal; Mitra, Saktimoyee; Pal, Prasun; Chakraborti, S. K. Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 595 - 599

全文：HTML全文

被引用次数: 24

摘要

It has been recognized'q2 in the past few years that a number of sesquiterpene lactones and other derivatives obtained from natural sources bearing a-methylene-ybutyrolactone and related moieties have exhibited interesting biological activity and significant antitumor activity. It soon was characterized that the O= CC= CH2 moiety itself, present in vernolepin, 2 elephantopin,* etc. is responsible for biological activity. The cytotoxic activity of a- ...