Structure− Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H-chromene-3-carboxylate (sHA 14-1) and Its …
…, SN Addo, B Srinivasan, DL Hermanson…
文献索引：Das, Sonia G.; Doshi, Jignesh M.; Tian, Defeng; Addo, Sadiya N.; Srinivasan, Balasubramanian; Hermanson, David L.; Xing, Chengguo Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 5937 - 5949
Rapid development of multiple drug resistance against current therapies is a major barrier in the treatment of cancer. Therefore, anticancer agents that can overcome acquired drug resistance in cancer cells are of great importance. Previously, we have demonstrated that ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H-chromene-3-carboxylate (5a, sHA 14- 1), a stable analogue of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4 H- ...
