The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine and 16-epiaffinine, as well as vobasinediol and 16-epivobasinediol
J Yang, SK Rallapalli, JM Cook
文献索引：Yang, Jie; Rallapalli, Sundari K.; Cook, James M. Tetrahedron Letters, 2010 , vol. 51, # 5 p. 815 - 817
Affinine (1) was first isolated from Peschiera affinis (Muell. Arg.) Miers (Apocynaceae) in 1963 by Weisbach et al., 1 while 16-epiaffinine (2) was isolated from the bark of Pleiocarpa talbotii Wernham. 2 These indole alkaloids belong to the family of 3-oxygenated sarpagine indole alkaloids which are a rare, but important group of bases because they comprise key components of a group of bisindole alkaloids shown to possess potent biological activity including ...
