Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry

…, K Lowery, V Mohan, S Hofstadler, EE Swayze…

文献索引：He, Yun; Yang, Jun; Wu, Baogen; Robinson, Dale; Sprankle, Kelly; Kung, Pei-Pei; Lowery, Kristin; Mohan; Hofstadler, Steve; Swayze, Eric E.; Griffey, Rich Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 695 - 699

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被引用次数: 29

摘要

The interactions between RNA and biological macromolecules are clearly essential for many vital processes in molecular biology, and the excitement over RNA-based viruses has fueled an interest in the development of potential RNA inhibitors. Recently, a considerable amount of attention has been focused on new RNA-binding molecules for drug discovery. 1, 2, 3, 4, 5, 6 and 7 RNA offers several selective advantages over DNA as a therapeutic agent. First, ...