Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers

JI McKenna, L Schlicksupp, NR Natale…

文献索引：McKenna; Schlicksupp; Natale; Willett; Maryanoff; Flaim Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 473 - 476

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被引用次数: 19

摘要

Diethyl 2, 6-dimethyl-4-(5-ethyl-3-phenylisoxazol-4-yl)-l, 4-dihydroypridine-3, 5- dicarboxylate (5) and diethyl 2, 6-dimethyl-4-(5-isopropyl-3-phenylisoxazol-4-yl)-1, 4- dihydrop~ idine-3, 5-dicarboxylate (6) were synthesized, and their molecular structures were determined by X-ray crystallography. In compound 5, which has an ethyl group at the C5 position of the isoxazole ring, the deviation from planarity in the dihydropyridine (DHP) ...