Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors
…, AK Verma, T Warchol, SB Levy, MN Alekshun
文献索引：Bowser, Todd E.; Bartlett, Victoria J.; Grier, Mark C.; Verma, Atul K.; Warchol, Taduesz; Levy, Stuart B.; Alekshun, Michael N. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5652 - 5655
Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse ...
