New dsDNA binding unnatural oligopeptides with pyrimidine selectivity

…, P Chaltin, A Van Aerschot, J Lacey, J Rozenski…

文献索引：Zhang, Zhenyu; Chaltin, Patrick; Van Aerschot, Arthur; Lacey, Jeff; Rozenski, Jef; Busson, Roger; Herdewijn, Piet Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3401 - 3413

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被引用次数: 15

摘要

Solid phase peptide library screening followed by extension of a lead recognition element for binding to a dsDNA sequence (NF binding site of IL6) using solution phase screening, delivered a new DNA binding peptide, Ac-Arg-Ual-Sar-Chi-Chi-Tal-Arg-CONH2. In the present research, the contribution of the different amino acid side chains to the binding strength of the peptide to dsDNA was investigated using an ethidium bromide ...