Preparations and Reactions of SF5??Substituted Aryl and Heteroaryl Derivatives via Mg and Zn Organometallics

…, K Groll, H Stadtmüller, P Knochel

文献索引：Frischmuth, Annette; Unsinn, Andreas; Groll, Klaus; Stadtmueller, Heinz; Knochel, Paul Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10234 - 10238

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被引用次数: 28

摘要

The physico-chemical and pharmacological properties of organic molecules are often significantly modified by the incorporation of fluorine atoms.[1] The preparation of fluoroor trifluoromethyl-substituted aromatics and hetero-ACHTUNGTRENNUNGaromatics has become an active research field.[2] Recently, it has been shown that the replacement of CF3 groups with SF5 substituents may increase the biological activity of pharmacologically ...