A series of 3-(4-phenoxyphenyl)-1 H-pyrazoles were synthesized and characterized as potent state-dependent sodium channel blockers. A limited SAR study was carried out to delineate the chemical requirements for potency. The results indicate that the distal phenyl group is critical for activity but will tolerate lipophilic (+ π) electronegative (+ σ) substituents at the ortho and/or para position. Substitution at the pyrazole nitrogen with a H-bond donor ...
