Synthesis and Anti??herpetic Activity of Phosphoramidate ProTides

…, G Andrei, R Snoeck, J Balzarini, P Herdewijn

文献索引：Maiti, Munmun; Persoons, Leentje; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Herdewijn, Piet ChemMedChem, 2013 , vol. 8, # 6 p. 985 - 993

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被引用次数: 3

摘要

Abstract Among the many prodrug approaches aimed at delivering nucleoside monophosphates into cells, the phosphoramidate ProTide approach is one that has shown success, which has made it possible for some of the phosphoramidates to enter into clinical trials. Herein, we report the synthesis and antiviral activity of a series of phosphoramidate ProTides designed to bypass the thymidine kinase (TK) dependence of the parent ...