Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures

…, R Ekkebus, H Lingeman, IJP Esch, J Kool…

文献索引：Eggink, Mark; Wijtmans, Maikel; Ekkebus, Reggy; Lingeman, Henk; De Esch, Iwan J. P.; Kool, Jeroen; Niessen, Wilfried M. A.; Irth, Hubertus Analytical Chemistry, 2008 , vol. 80, # 23 p. 9042 - 9051

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被引用次数: 72

摘要

In LC− MS, derivatization is primarily used to improve ionization characteristics, especially for analytes that are not (efficiently) ionized by ESI or APCI such as aldehydes, sugars, and steroids. Derivatization strategies are then directed at the incorporation of a group with a permanent charge. A compound class that typically requires derivatization prior to LC− MS is the group of small aliphatic aldehydes that are, for instance, analyzed as the key ...