Synthesis by microwave irradiation and binding properties of novel 5-HT 1A receptor ligands

…, E Perissutti, B Severino, S Gessi, E Cattabriga…

文献索引：Caliendo, Giuseppe; Fiorino, Ferdinando; Perissutti, Elisa; Severino, Beatrice; Gessi, Stefania; Cattabriga, Elena; Borea, Pier Andrea; Santagada, Vincenzo European Journal of Medicinal Chemistry, 2001 , vol. 36, # 11-12 p. 873 - 886

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被引用次数: 43

摘要

This work reports the synthesis by microwave irradiation and the binding tests on the 5- HT1A, 5-HT2A and 5-HT2C receptors of new substituted piperazines in order to identify selective ligands for 5-HT1A subtype receptor. Conventional heating and microwave irradiation of the reactions was compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The ...