Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors

R Sheng, X Lin, J Li, Y Jiang, Z Shang, Y Hu

文献索引：Sheng, Rong; Lin, Xiao; Li, Jingya; Jiang, Yanke; Shang, Zhicai; Hu, Yongzhou Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3834 - 3837

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被引用次数: 66

摘要

A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50= 50nM), and the molecular docking study indicated that it was nicely accommodated by AChE.